產(chǎn)品編號：Y0192

英文名稱：Thiabendazole

CAS號 148-79-8 

分析標(biāo)準(zhǔn)品

分子式 C10H7N3S 分子量201.25

基本信息:

密度  1.4060

熔點  304-305°C

溶解性  Soluble in ethanol (1 mg/ml), DMF (50 mg/ml), chlorinated hydrocarbons (slightly), DMSO (40 mg/ml), and water (<1 mg/ml).

描述

產(chǎn)品介紹  不溶于水，微溶于醇、丙酮，易溶于乙醚、氯仿。

別名  噻苯咪唑;噻苯唑;2-(1,3-噻唑-4-基)苯并咪唑;2-(4-噻唑基)苯并咪唑;2-(4-Thiazolyl)benzimidazole; 2-(thiazol-4-yl)benzimidazole; 2-(1,3-Thiazol-4-yl)benzimidazole; Mintezol; Mintesol; Omnizole;Lombristop; Thiabendazol

生化機(jī)理  Thiabendazole inhibits anaerobic respiration at the level of mitochondrial helminth-specific enzyme. It acts as a quinol-fumarate reductase (QFR) inhibitor in ,C. jejuni and H. pylori, blocking quinol oxidation to quinone. Thiabendazole suppresses egg and larval production and may inhibit the subsequent development of eggs and larvae which are passed in feces2. A proposed route of biotransformation of thiabendazole is the CYP1A2-catalyzed hydroxylation to 5-hydroxythiabendazole, which is metabolized to glucuronide and sulfate conjugates.

應(yīng)用  內(nèi)吸性殺菌劑。能防止多種植物的真菌病害，用于處理收獲后的水果和蔬菜，可防止貯存中發(fā)生的上些病害，目前國內(nèi)外已廣泛應(yīng)用。